主要从事微生物感染与神经免疫相关研究，重点关注真菌感染的免疫识别及应答机制，探讨微生物对神经系统的影响机制。相关研究成果以第一作者或通讯作者身份发表在Nature Communications、Cell Host & Microbe、Trends in Microbiology、Proceedings of the National Academy of Sciences (PNAS)等杂志。作为项目负责人，承担国家自然科学基金、上海市科委项目等科研项目。
I specialize in research at the intersection of microbial infections and neuroimmunology, with a particular emphasis on the immune recognition and response mechanisms associated with fungal infections. My work also explores the impact of microorganisms on the nervous system. I have published findings as the first or corresponding author in journals including Nature Communications, Cell Host & Microbe, Trends in Microbiology, and Proceedings of the National Academy of Sciences (PNAS). As the project leader, I have undertaken research projects funded by the National Natural Science Foundation of China and the Science and Technology Commission of Shanghai.
代表性论文：
Representative publications：
Hui Wang, Yi-Heng Yang, Jia-Jie Tang, Xian-Long Wang, Xin-Yi Liu, Han Wang, Han-Yu Wang, Rong-Rong Wang, Hui-Hui Ma, Yebo Gu*, Xin-Ming Jia*. Epigenetic repression of IL-1β by C1QBP restricts Dectin-1-mediated host defense against murine invasive candidiasis. Nature Communications 2026. (*Corresponding author)
Yi-Heng Yang, Ke-Fang Xie, Shuai Yang, Huan Wang, Hui-Hui Ma, Min Zhou, Zhong-Wei Wang, Yebo Gu*, Xin-Ming Jia*. BLNK negatively regulates C-type lectin receptor-mediated antifungal immunity through inhibiting macrophage migration. PNAS 2024 Oct 22;121(43); (*Corresponding author)
Fan Li#, Hui Wang#, Yan-Qi Li, Yebo Gu*, Xin-Ming Jia*. C-type lectin receptor 2d forms homodimers and heterodimers with TLR2 to negatively regulate IRF5-mediated antifungal immunity. Nature Communications 2023; 14(1): 6718. (*Corresponding author, Featured article at Nature Communications)
Yebo Gu#, Xin-Ming Jia*. STING negatively regulates antifungal immunity. Trends in Microbiology 2023; 31(11): 1090-1092.
Yebo Gu#, Xin-Ming Jia*. Stealth strategies of Candida albicans to evade host immunity. Cell Host & Microbe 2024 Sep 11;32(9):1459-1461.
Yebo Gu#, Zhou Wu, Fan Zeng, Muzhou Jiang, Jessica L Teeling, Junjun Ni, Ichiro Takahashi. Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis Induces Bone Loss-Correlated Alzheimer's Disease-Like Pathologies in Middle-Aged Mice. Journal of Alzheimer’s Disease 2020; 78(1):61-74.
Wang Y, Zhao J, Gu Y#, Wang H, Jiang M, Zhao S, Qing H, Ni J. Cathepsin H: Molecular characteristics and clues to function and mechanism. Biochem Pharmacol. 2023 Jun;212:115585. doi: 10.1016/j.bcp.2023.115585. Epub 2023 May 5. PMID: 37148981.
Yebo Gu#, Han-Yu Wang#, Ya-Shu Wang#, Linqi Wang, Xin-Ming Jia. Challenges posed by fungi to host immunity:Mechanisms of immune evasion. hLife, 2026
Yebo Gu#, Yashu Wang#, Hanyu Wang#, Xin-Ming Jia. Molecular interplay in CNS fungal invasion: Strategies for Invasion, Immune Evasion, and Host Countermeasures. iFungi, 2026
科研项目：
国家自然科学基金, 面上项目,主持；
国家自然科学基金, 青年科学基金项目,主持；
上海市科委, “科技创新行动计划”启明星项目（扬帆专项）,主持；
科技部, 国家重点研发计划“国家质量基础设施体系”重点专项，课题骨干；
科技部, 国家重点研发计划“病原学与防疫技术体系研究”重点专项，课题骨干；
伟德下载伟德官网自主原创基础研究项目，主持
Research projects:
General Program of National Natural Science Foundation of China
The Young Scientists Fund of National Natural Science Foundation of China
Grants from the National Natural Science Foundation of China;
Grants from the Shanghai Sailing Program, the Science and Technology Commission of Shanghai;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “National Quality Infrastructure System” Key Special Project;
Grants from Ministry of Science and Technology, National Key Research and Development Program of China, “Research on Pathogen and Preventive Technology Systems” Key Special Project;
Grants from Tongji University Original Basic Research Project
