英国伦敦大学附属皇家骨科医院访问学者，美国加州大学旧金山总院访问学者。主要从事骨科创伤与四肢软组织损伤的治疗与关节重建临床与基础研究，在国内率先开展可吸收内固定技术及微创新技术治疗关节内外骨折；尤其在骨盆骨折伴骶丛损伤的这一世界性难题领域，具有较高的造诣，解决了部分损伤患者的肢体残疾和排尿障碍等临床问题，在骶骨骨折与骶丛损伤这一领域的治疗和研究水平处于国内外领先地位。基于以上长期工作积累，以第一完成人获得教育部科技进步一等奖1项,军队医疗成果二等奖1项，主持6项国家自然科学基金面上项目，指导学生获得一项国家自然科学基金青年项目，以第一或通讯作者发表SCI论文50篇，培养博、硕士研究生二十二人，其中1人获得华人生物学在读博士最高奖 “吴瑞奖”，1人获得中华医学会显微外科分会中青年论文竞赛一等奖，1人获得上海市骨科年会中青年论文竞赛一等奖，1人获得上海市显微外科年会中青年论文竞赛一等奖，2人获得大学研究生论文评比一等奖。基于这些临床带研成绩，获得“第二军医大学我心中喜爱导师”称号。在2026世界杯赛程任兼职教授以来，培养博士研究生3名，其中1人获“国家自然科学基金（青年）”，一人获连续两年获国家奖学金（2024，2025年）。
As a visiting scholar at the Royal Orthopaedic Hospital, University of London and the General Hospital, University of California, San Francisco. Aimin Chen mainly engaged in clinical and basic research on the treatment of orthopedic trauma and soft tissue injury of extremities and joint reconstruction. He firstly develop absorbable internal fixation technology and micro-innovative technology for the treatment of internal and external joint fractures in China. Partly solved the worldwide problem of sacral fracture with sacral plexus injury, solved the limb disability and urination disorder of some patients, and improved the clinical efficacy. At present, the team is in the leading position in the treatment and research of sacral fractures and sacral plexus injuries in China. Based on the above work accumulated for a long time, won 1 first prize of science and technology progress of the Ministry of Education, 1 second prize of military medical achievements, presided over 6 items of national natural science foundation of China, published more than 40 SCI papers, trained more than 20 postgraduate students and won the title of "My Favorite Tutor of the Second Military Medical University". Among the studednts, 1 won the "Wu Rui Award", 1 won the first prize of the Young and middle-aged paper competition of the Microsurgery Society of Chinese Medical Association, 1 won the first prize of the Young and Middle-aged paper competition of the Shanghai Microsurgery Annual Meeting, and 2 won the first prize of the university graduate paper competition. Since serving as an adjunct professor at Tongji University, I have supervised the doctoral studies of 3 students. Among them, one received the "National Natural Science Foundation (Young Researcher)" award, and another was awarded the National Scholarship for two consecutive years (in 2024 and 2025).
一、主持科研项目
1、国家自然基金面上项目（National Natural Scientific Foundation of China）：Caspase-1相关环状RNA在骶神经损伤后脊髓后角感觉神经元焦亡中的作用及机制研究，82171371，55万，2022-2025，在研，主持。
2、国家自然基金面上项目（National Natural Scientific Foundation of China）：环状RNA的差异表达对骶神经根性撕脱伤后脊髓前角神经元自噬的影响及其机制研究，81874003，58万，2019-2022年，已结题，主持。
3、国家自然基金面上项目（National Natural Scientific Foundation of China）：骶丛神经撕脱伤后脊髓前角神经元发生自噬及其机制研究，81571204，68万，2015-2018 ，已结题，主持。
4、国家自然基金面上项目（National Natural Scientific Foundation of China）：干细胞移植对骶丛损伤修复后靶细胞退变影响及机制研究，81272012，70万，2012-2015，已结题，主持。
5、国家自然基金面上项目（National Natural Scientific Foundation of China）：腰2神经根移位修复骶丛损伤靶细胞退变及中枢神经功能重塑研究，81171161，54万，2011-2014，已结题，主持。
6、国家自然基金面上项目（National Natural Scientific Foundation of China）：健侧骶神经根作为新动力源神经修复骶神经根撕脱伤研究，30973054，32万，2009-2012，已结题，主持。
7、省级重大公关专项（Major military innovation projects）：新型手术床的开发与研究，200万，2019-2023，在研，主持。
8、省级重大创新专项（Major military special fund）：骶骨骨折伴骶丛损伤治疗新技术研究，200万，2015-2018，已结题，主持。
二、近10年发表＞5分SCI论文情况，最高影响因子15.3分
1. Wang S, Lu N, Liu J, Li Y, Xiong L, Chen A. Anterior lumbar‒iliac fixation for unstable pelvic fractures: a novel surgical technique. Int J Surg. 2025 Aug 7. doi: 10.1097/JS9.0000000000002958. Epub ahead of print. 通讯作者.
2. Mao J, Lu J, Wang S, Jiang X, Li J, Fu Q, Lu N, Zhu L, Chen A, Ma J. Hydrogen sulfide protects against spinal cord pyroptosis via persulfidation of Rac1 after lumbosacral plexus nerve injury. Cell Death Discov. 2025 Oct 6;11(1):436. doi: 10.1038/s41420-025-02736-x. 通讯作者.
3. Lu J, Li Y, Cai J, Jin X, Chu G, Jin H, Zhu L, Chen A. Biocompatibility and therapeutic efficacy of crosslinked hydrogel filled 3D-printed nerve conduit for sacral nerve injury repair. Biomaterials. 2025 Sep;320:123230. doi: 10.1016/j.biomaterials.2025.123230. Epub 2025 Mar 3. Erratum in: Biomaterials. 2026 Jan;324:123485. doi: 10.1016/j.biomaterials.2025.123485. 通讯作者.
4. Lu J, Shi X, Zhou Z, Lu N, Chu G, Jin H, Zhu L, Chen A. Enhancing Fracture Healing with 3D Bioprinted Hif1a-Overexpressing BMSCs Hydrogel: A Novel Approach to Accelerated Bone Repair. Adv Healthc Mater. 2025 Jan;14(3):e2402415. doi: 10.1002/adhm.202402415. Epub 2024 Nov 24.
5. Wang S, Xia D, Dou W, Chen A, Xu S. Bioactive Porous Composite Implant Guides Mesenchymal Stem Cell Differentiation and Migration to Accelerate Bone Reconstruction. Int J Nanomedicine. 2024 Nov 19;19:12111-12127. doi: 10.2147/IJN.S479893. PMID: 39583325; 通讯作者.
6. Shi X, Fu Q, Mao J, Yang J, Chen Y, Lu J, Chen A, Lu N.Integration of single-cell and RNA-seq data to explore the role of focal adhesion-related genes in osteoporosis. J Cell Mol Med. 2024 Apr;28(8):e18271. doi: 10.1111/jcmm.18271. 通讯作者.
7. Wang S, Xia D, Song D, Lu N, Chen A.Could nerve transplantation be the future of this field: a bibliometric analysis about lumbosacral plexus injury. Int J Surg. 2024 Jun 1;110(6):3734-3744. doi: 10.1097/JS9.0000000000001332.PMID: 38518081. 通讯作者.
8. Zhibin Zhou, Jun Ma, Jiajia Lu, Aimin Chen, Lei Zhu. 2Circular RNA CircCDH13 contributes to the pathogenesis of osteoarthritis via CircCDH13/miR-296-3p/PTEN axis. J Cell Physiol.2021;236(5):3521-3535.通讯作者.
9. Jun Ma, Lei Zhu, Zhibin Zhou, Tengfei Song, Lei Yang, Xu Yan, Aimin Chen, Tian Wen Ye. The calcium channel TRPV6 is a novel regulator of RANKL induced osteoclastic differentiation and bone absorption activity through the IGF–PI3K–AKT pathway. Cell Prolif.2021;54(1):e12955. 通讯作者.
10. Jun Ma, Di Du, Jia Liu, Lei Guo, Yongchuan Li, Aimin Chen, TianWen Ye. Hydrogen sulphide promotes osteoclastogenesis by inhibiting autophagy through the PI3K/AKT/mTOR pathway. J Drug Target.2020;28(2):176-185. 通讯作者.
11. Jiajia Lu, Zhibin Zhou, Jun Ma, Nan Lu, Zhu Lei, Di Du, Aimin Chen. Tumour necrosis factor-a promotes BMHSC differentiation by increasing P2X7 receptor in oestrogen-deficient osteoporosis. J Cell Mol Med.2020;24(24):14316-14324. 通讯作者.
12. Zhi-Bin Zhou, Gao-Xiang Huang, Qiang Fu, Bin Han, Jia-Jia Lu, Ai-Min Chen, Lei Zhu.circRNA.33186 Contributes to the Pathogenesis of Osteoarthritis by Sponging miR-127-5p. Mol Ther.2019;27(3):531-541. 通讯作者.
13. Zhi-Bin Zhou, Yu-Long Niu, Gao-Xiang Huang, Jia-Jia Lu, Aimin Chen, Lei Zhu. Silencing of circRNA.2837 plays a protective role in sciatic nerve injury by sponging the miR-34 family via regulating neuronal autophagy. Mol Ther Nucleic Acids.2018;12:718-729. 通讯作者.
14. L Zhu, F Zhang, D Yang, A Chen. The effect of severing a normal S1 nerve root to use for reconstruction of an avulsed contralateral lumbosacral plexus: a pilot study. Bone Joint J. 2015;97-B(3):358-65. 通讯作者.
三、获奖情况
1. 教育部科技进步一等奖，复杂骨盆损伤及关节骨折治疗新技术研究，2014年，排名第1。
2. 省部级医疗成果二等奖，可吸收内固定的基础与临床运用研究，2006年，排名第1。
3. 军队科技进步二等奖，几丁质几丁糖作为外科充填剂和载体的基础与临床研究，排名第2。
4. 国家科学技术进步二等奖，水溶性几丁糖医用制品的研制与运用，2009年，排名第6。
5. 上海市医学奖二等奖，严重肩部创伤治疗的基础与临床研究，2019年，排名第4。
6. 上海市科学技术进步奖，水溶性医用几丁糖的制备技术与运用，2008年，排名第6。
7.上海市科学技术进步奖，几丁糖的基础与运用研究，1998年，排名第4。
8.省部级科技进步奖，小血管端侧吻合血流动力学研究与临床运用，1997年，排名第6。
