鼻黏膜慢性炎症与神经免疫调控

Chronic inflammation of the nasal mucosa and neuroimmune regulation

上海市医学会耳鼻咽喉头颈外科分会委员

Member of Otolaryngology Head and Neck Surgery Committee of Shanghai Medical Association

上海市医学会变态反应专科分会委员

Member of Allergy Committee of Shanghai Medical Association

中国中西医结合学会耳鼻咽喉科专业委员会委员

Member of Otolaryngology Committee of Chinese Association of Integrative Medicine

中国人体健康科技促进会鼻科专业委员会委员

Member of Rhinology Committee of China Association for Promotion of Health Science and Technology

上海健康教育促进会听觉防护与康复专业委员会委员

Member of Hearing Protection and Rehabilitation Committee of Shanghai Association for Promotion of Health Education

浦东新区医学会耳鼻咽喉头颈外科分会副主任委员

Vice Chairman of Otolaryngology Head and Neck Surgery Committee of Pudong New Area Medical Association

主持国家自然科学基金青年项目、上海市自然科学基金面上项目、上海市卫健委临床研究面上项目、浦东新区科委面上项目及浦东新区卫健委面上项目等研究。发表论文35篇，其中SCI收录18篇。授权国家专利7项，其中发明专利2项。参与译著2部，编著1部，主译1部。获得上海市十佳优秀青年医师奖等称号。

He has presided over research projects such as National Natural Science Foundation of China, Shanghai Natural Science Foundation, Shanghai Municipal Health Commission Clinical Research Project, Pudong New Area Science and Technology Commission Project, and Pudong New Area Health Commission Project. He has published 35 papers, among which 18 are indexed by SCI. He has been granted 7 national patents, including 2 invention patents. He has participated in the translation of 2 books, authored 1 book, and served as the main translator of 1 book. He has received titles such as the Shanghai Top Ten Outstanding Young Physicians Award.

【近期发表文章（Recent Publication List）】

1. Zhang Y, Ruan S, Xie Y, Rui X, Zhou J, Wang W. Peroxisome proliferator-activated receptor gamma prevents activation of RBL-2H3 cells by inhibiting FcεRI-mediated signal transduction. Inflamm Res. 2025 Mar 8;74(1):49.

2. Rui X, Ruan S, Zhang Y, Fu R, Sun P, Lamu D, Wang W. PPAR γ Modulates CD4+ T-Cell Differentiation and Allergic Inflammation in Allergic Rhinitis: A Potential Therapeutic Target. Biomedicines. 2025 Jul 1;13(7):1616.

3. Wang W, Ruan S, Xie Y, Fang S, Yang J, Li X, Zhang Y. Development and Validation of a Pathomics Model Using Machine Learning to Predict CXCL8 Expression and Prognosis in Head and Neck Cancer. Clin Exp Otorhinolaryngol. 2024 Feb;17(1):85-97.

4. Fang S, Rui X, Zhang Y, Yang Z, Wang W. Comparative study of nasal cavity drug delivery efficiency with different nozzles in a 3D printed model. PeerJ. 2024 Apr 10;12:e17227.

5. Huang Y, Zhang F, Chen H, Ren D, Yu H, Du Q, Gao C, Shi Y, Liang Y, Xu C, Wang W, Hu H, Sun Q, Zhang R, Zhang J, Wu H, Shao J, He P. Risk Factors of Difficult Pharyngeal Accidental Fishbones Ingestion. Ear Nose Throat J. 2024 Mar;103(3):168-172.

6. Xu M, Wang C, Fang S, Rui X, Ying L, Ma Z, Wang W. Effect of recombinant human acidic fibroblast growth factor on nasal mucosal healing after endoscopic sinus surgery. Am J Otolaryngol. 2023 Jul-Aug;44(4):103895.

7. Wei X, Xu M, Wang C, Fang S, Zhang Y, Wang W. Genome-wide analysis of long noncoding RNA expression profile in nasal mucosa with allergic rhinitis. BMC Med Genomics. 2021 Apr 9;14(1):100.

8. Fang S, Wei X, Ying L, Zhu L, Cui J, Ma Z, Wang W. Comparative study of nasal septal retainer and nasal packing in patients undergoing septoplasty. Eur Arch Otorhinolaryngol. 2019 Aug;276(8):2251-2257.

9. Fang S, Li X, Wei X, Zhang Y, Ma Z, Wei Y, Wang W. Beneficial effects of hydrogen gas inhalation on a murine model of allergic rhinitis. Exp Ther Med. 2018 Dec;16(6):5178-5184.